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Topoisomerase I poison-triggered immune gene activation is markedly reduced in human small-cell lung cancers by impairment of the cGAS/STING pathway.

Jessica MarinelloAndrea ArleoMarco RussoMaria DelcuratoloFrancesca CiccarelliYves PommierGiovanni Capranico
Published in: British journal of cancer (2022)
Altogether, our data reveal an immune signalling mechanism activated by TOP1 poisons, which is often impaired in human SCLC tumours.
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