Role of tumor infiltrating lymphocytes and spatial immune heterogeneity in sensitivity to PD-1 axis blockers in non-small cell lung cancer.

Miguel Lopez de RodasVenkata NagineniArvind RaviIla J DatarMari A Mino-KenudsonGerman CorredorCristian BarreraLindsey BehlmanDavid L RimmRoy S HerbstAnant MadabhushiJonathan W RiessVamsidhar VelchetiMatthew D HellmannJustin GainorKurt A Schalper

Published in: Journal for immunotherapy of cancer (2022)

Baseline T cell density and T cell exhaustion marker expression can stratify outcomes in PD-L1 positive patients with NSCLC treated with ICI. Spatial immune heterogeneity can be measured using the RQI and is associated with survival in NSCLC.

Keyphrases

small cell lung cancer
single cell
advanced non small cell lung cancer
poor prognosis
brain metastases
peripheral blood
type diabetes
binding protein
free survival
metabolic syndrome
newly diagnosed
insulin resistance
weight loss
glycemic control