Is tocilizumab monotherapy as effective in preventing radiographic progression in rheumatoid arthritis as its combination with methotrexate?

Maxime M A VerhoevenJanneke TekstraJohannes W G JacobsJohannes W J BijlsmaJacob M van LaarAttila Pethö-SchrammMichelle E A BormFloris P J LafeberPaco M J Welsing

Published in: Arthritis care & research (2020)

Combination therapy with TCZ+MTX is more effective in preventing radiographic progression compared to TCZ-monotherapy, but the effectiveness of TCZ-monotherapy may approximate the effectiveness of TCZ+MTX in early RA patients with more joint damage and/or a lower DAS28 at baseline, and in established RA patients with longer disease duration.

Keyphrases

combination therapy
rheumatoid arthritis
disease activity
rheumatoid arthritis patients
randomized controlled trial
ankylosing spondylitis
systematic review
juvenile idiopathic arthritis
interstitial lung disease
systemic lupus erythematosus
high dose
oxidative stress
open label
clinical trial