Promoter methylation of the glucocorticoid receptor following trauma may be associated with subsequent development of PTSD.

Lior CarmiJoseph ZoharAlzbeta Juven-WetzlerFrank DesarnaudIouri MakotkineLinda M BiererHagit CohenRachel Yehuda

Published in: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry (2023)

To the extent that reduced promoter methylation is associated with greater GR expression and responsivity, this finding is consistent with the hypothalamic-pituitary-adrenal dysregulation previously described for PTSD.

Keyphrases

dna methylation
genome wide
posttraumatic stress disorder
gene expression
poor prognosis
social support
transcription factor
binding protein
depressive symptoms