Depressive effectiveness of vigabatrin (γ-vinyl-GABA), an antiepileptic drug, in intermediate-conductance calcium-activated potassium channels in human glioma cells.

Te-Yu HungHuai-Ying Ingrid HuangSheng-Nan WuChin-Wei Huang

Published in: BMC pharmacology & toxicology (2021)

The inhibitory effect of VGB on IKCa channels demonstrated in the current study could be an important underlying mechanism of VGB-induced antineoplastic (e.g., anti-glioma) actions.

Keyphrases

systematic review
endothelial cells
high glucose
drug induced
diabetic rats
randomized controlled trial
emergency department
stress induced
pluripotent stem cells