Reduction of pro-inflammatory effector functions through remodeling of fatty acid metabolism in CD8 + T-cells from rheumatoid arthritis patients.

Franziska V KrausSimon KeckKarel D KlikaJürgen GrafRui A CarvalhoHanns-Martin LorenzM Margarida Souto-Carneiro

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2023)

RA CD8 present an altered FA metabolism which can provide potential therapeutic targets to control the pro-inflammatory profile. Particularly, therapies directed against the transport and oxidation of free FA.

Keyphrases

rheumatoid arthritis patients
disease activity
fatty acid
rheumatoid arthritis
systemic lupus erythematosus
ankylosing spondylitis
regulatory t cells
dendritic cells
hydrogen peroxide
immune response
type iii
nk cells
electron transfer