Blood protein profiles related to preterm birth and retinopathy of prematurity.
Hanna DanielssonAbdellah TebaniWen ZhongLinn FagerbergNele BrusselaersAnna-Lena HårdMathias UhlénAnn HellströmPublished in: Pediatric research (2021)
Longitudinal protein profiles of 14 extremely preterm infants were analyzed using a novel multiplex protein analysis platform combined with perinatal data. Proteins associated with gestational age at birth and the neurovascular disease ROP were identified. Among infants with ROP, longitudinal levels of the identified proteins remained largely unchanged during the first postnatal months. The main functions of the proteins identified were angiogenesis, hematopoiesis, immune function, bone regulation, lipid metabolism, and central nervous system development. The study contributes to the understanding of longitudinal serum protein patterns related to gestational age and their association with abnormal retinal neuro-vascular development.
Keyphrases
- gestational age
- preterm birth
- birth weight
- preterm infants
- low birth weight
- protein protein
- cross sectional
- high throughput
- pregnant women
- optical coherence tomography
- bone mineral density
- machine learning
- small molecule
- physical activity
- deep learning
- body mass index
- weight loss
- big data
- postmenopausal women
- electronic health record
- cerebrospinal fluid
- pregnancy outcomes
- fatty acid
- real time pcr