Expression of sterile-α and armadillo motif containing protein (SARM) in rheumatoid arthritis monocytes correlates with TLR2-induced IL-1β and disease activity.
Ryan S ThwaitesSarah UnterbergerGiselle ChamberlainHenry GrayKelsey JordanKevin A DaviesNeil A HarrisonSandra M SacrePublished in: Rheumatology (Oxford, England) (2021)
Together, these data highlight a potential contribution from SARM to RA pathophysiology where decreased SARM may lead to elevated IL-1β associated with RA pathogenesis. Furthermore, the data additionally present a potential mechanism by which TNF-α blockade can modify IL-1β secretion.
Keyphrases
- rheumatoid arthritis
- disease activity
- ankylosing spondylitis
- systemic lupus erythematosus
- rheumatoid arthritis patients
- juvenile idiopathic arthritis
- electronic health record
- interstitial lung disease
- big data
- poor prognosis
- inflammatory response
- binding protein
- immune response
- risk assessment
- oxidative stress
- deep learning
- idiopathic pulmonary fibrosis