3D chromosomal landscape reveals miR-146a dysfunctional enhancer in lupus and establishes a CRISPR-mediated approach to inhibit the IFN pathway.
Xinyi ZhuYutong ZhangZihang YinZhizhong YeYuting QinZhaorui ChengYiwei ShenZhihua YinJianyang MaYuanjia TangHuihua DingYa GuoGuojun HouNan ShenPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2023)
Our work defines a promising target for SLE intervention. We adopted integrative approaches to define cell-specific and functional enhancers of the SLE critical gene, and investigated the mechanism underlying its dysregulation mediated by a lupus-related enhancer.
Keyphrases
- systemic lupus erythematosus
- disease activity
- genome wide
- single cell
- rheumatoid arthritis
- copy number
- transcription factor
- binding protein
- randomized controlled trial
- cell proliferation
- long non coding rna
- crispr cas
- genome editing
- dendritic cells
- dna methylation
- stem cells
- gene expression
- mesenchymal stem cells
- drug induced