Frizzled does not get bent out of shape by Wnt.

Ligands of the Wnt family activate the Frizzled-LRP5/6 receptor complex to initiate intracellular signaling. In this issue of Science Signaling , Mahoney et al. reveal a Wnt-stimulated positive feedback loop that involves local production of the lipid phosphatidylinositol(4,5)bisphosphate [PI(4,5)P 2 ], which promotes Dishevelled recruitment and additional PI(4,5)P 2 production, to facilitate LRP5/6 phosphorylation.