Targeting the dendritic cell-secreted immunoregulatory cytokine CCL22 alleviates radioresistance.

Jason Bugno Liangliang Wang Xianbin Yu Xuezhi Cao Jiaai Wang Xiaona Huang Kaiting Yang Andras Piffko Katherine Chen Stephen Y Luo Emile Naccasha Yuzhu Hou Sherry Fu Chuan He Yang-Xin Fu Hua Laura Liang Ralph R Weichselbaum

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

We identify a previously unappreciated cDC mechanism mediating Treg tumor infiltration after RT. Our findings suggest blocking the cDC1-CCL22-Treg axis augments RT efficacy. αEGFR-IFNα added to RT provided robust antitumor responses better than systemic free interferon administration, and may overcome clinical limitations to interferon therapy. Our findings highlight the complex behavior of cDC after RT and provide novel therapeutic strategies for overcoming RT-driven immunosuppression to improve RT efficacy.

Keyphrases

dendritic cells
small cell lung cancer
cell cycle
regulatory t cells
stem cells
liver fibrosis
tyrosine kinase
oxidative stress
cell proliferation
bone marrow
drug induced