Genetic variants in humanin nuclear isoform gene regions show no association with coronary artery disease.
Mall EltermaaMaili JakobsonMeeme UttSulev KõksReedik MägiJoel StarkopfPublished in: BMC research notes (2019)
Lookup from meta-analysis datasets gave single nucleotide polymorphisms in all 13 humanin-like nuclear isoform genes with the lowest P value for rs6151662 from the MTRNR2L2 gene including the 50 kb flanking region in both directions (P-value = 0.0037). Within the gene region alone the top variant was rs78083998 from the MTRNR2L13 region (meta-analysis P-value = 0.042). None of the found associations were statistically significant after correction for multiple testing. Lookup for expression trait loci in these gene regions gave no statistically significant variants.
Keyphrases
- genome wide
- copy number
- systematic review
- genome wide identification
- coronary artery disease
- dna methylation
- meta analyses
- poor prognosis
- genome wide analysis
- heart failure
- randomized controlled trial
- cardiovascular disease
- type diabetes
- transcription factor
- binding protein
- cardiovascular events
- atrial fibrillation
- single cell
- rna seq
- ejection fraction