Remote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome.
Laura M BartosStefanie LietkeValerio ZenattiSabrina V KirchleitnerJens BlobnerKarin Wind-MarkZeynep Ilgin KolabasSelin UlukayaAdrien HolzgreveViktoria C RufLea Helena KunzeSebastian T KunteLeonie HoermannMarlies HärtelHa Eun ParkMattes GroßNicolai FranzmeierArtem ZatcepinAdrian ZounekLena KaiserMarkus J RiemenschneiderMatthias BrendelBoris-Stephan RauchmannSophia StoeckleinSibylle ZieglerJochen HermsAli ErturkJoerg-Christian TonnNiklas ThonLouisa von BaumgartenMatthias PrestelSabina TahirovicNathalie L AlbertMatthias BrendelPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Neuroinflammation within the contralateral hemisphere can be detected with TSPO-PET imaging and associates with poor outcome in patients with newly diagnosed glioblastoma. The molecular signature of remote neuroinflammation promotes the evaluation of immunomodulatory strategies in patients with detrimental whole brain inflammation as reflected by high TSPO expression.
Keyphrases
- pet imaging
- newly diagnosed
- cerebral ischemia
- lipopolysaccharide induced
- lps induced
- traumatic brain injury
- cognitive impairment
- positron emission tomography
- poor prognosis
- inflammatory response
- oxidative stress
- blood brain barrier
- subarachnoid hemorrhage
- brain injury
- binding protein
- multiple sclerosis
- long non coding rna