Coding and Noncoding Variation in LRRK2 and Parkinson's Disease Risk.

Julie LakeXylena ReedRebekah G LangstonMike A NallsZiv Gan Or Mark R CooksonAndrew B SingletonCornelis BlauwendraatHampton L Leonardnull null

Published in: Movement disorders : official journal of the Movement Disorder Society (2021)

These data suggest that the LRRK2 coding variants previously related to PD (p.N551K, p.R1398H, p.M1646T, and p.N2081D) do not drive the 5' noncoding GWAS signal. These data, however, do not preclude the independent association of the haplotype p.N551K-p.R1398H and p.M1646T with altered disease risk. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson Movement Disorder Society. This article has been contributed to by US Government employees and their work is in the public domain in the USA.

Keyphrases

electronic health record
healthcare
big data
mental health
randomized controlled trial
emergency department
machine learning
systematic review
copy number
gene expression
dna methylation
data analysis
artificial intelligence
meta analyses