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Protocol for a multicentre randomised controlled trial examining the effects of temporarily pausing Bruton tyrosine kinase inhibitor therapy to coincide with SARS-CoV-2 vaccination and its impact on immune responses in patients with chronic lymphocytic leukaemia.

Vicki S BarberNicholas PeckhamLelia DuleyAnne FrancisAbhishek AbhishekPaul MossJonathan Alistair CookHelen M Parry
Published in: BMJ open (2023)
ISRCTN14197181.
Keyphrases
  • sars cov
  • study protocol
  • immune response
  • randomized controlled trial
  • respiratory syndrome coronavirus
  • clinical trial
  • dendritic cells
  • cross sectional
  • double blind
  • stem cells
  • cell therapy
  • replacement therapy