[89Zr]A2cDb Immuno-PET of Prostate Cancer in a Human Prostate Stem Cell Antigen Knock-in (hPSCA KI) Syngeneic Model.
Kirstin A ZettlitzWen-Ting K TsaiScott M KnowlesFelix B SalazarNaoko KobayashiRobert E ReiterAnna M WuPublished in: Molecular imaging and biology (2021)
Tracer biodistribution was not significantly impacted by normal tissue expression of PSCA. [89Zr]A2cDb immuno-PET yielded high tumor-to-blood ratio at early time points. Rapid renal clearance of the 50 kDa tracer resulted in an unobstructed view of the pelvic region at 20 h postinjection that would allow the detection of cancer in the prostate.
Keyphrases
- pet imaging
- prostate cancer
- stem cells
- loop mediated isothermal amplification
- positron emission tomography
- radical prostatectomy
- endothelial cells
- papillary thyroid
- poor prognosis
- computed tomography
- benign prostatic hyperplasia
- squamous cell
- induced pluripotent stem cells
- rectal cancer
- neoadjuvant chemotherapy
- heat shock protein
- pluripotent stem cells
- binding protein
- label free
- squamous cell carcinoma
- real time pcr
- sensitive detection
- young adults
- pet ct
- childhood cancer
- lymph node
- radiation therapy
- quantum dots
- iron oxide nanoparticles