Role of peroxisome proliferators-activated receptor-gamma in advanced glycation end product-mediated functional loss of voltage-gated potassium channel in rat coronary arteries.
Side GaoBing HuaQingbo LiuHuirong LiuWei-Ping LiHongwei LiPublished in: BMC cardiovascular disorders (2020)
AGE reduces the Kv channel expression in CSMCs and further impairs the Kv channel-mediated dilation in RSCAs. The AGE/RAGE axis may enhance oxidative stress by inhibiting the downstream PPAR-γ pathway, thus playing a critical role in the dysfunction of Kv channels.
Keyphrases
- oxidative stress
- image quality
- poor prognosis
- coronary artery disease
- coronary artery
- dna damage
- binding protein
- signaling pathway
- insulin resistance
- diabetic rats
- induced apoptosis
- ischemia reperfusion injury
- heart failure
- metabolic syndrome
- long non coding rna
- blood flow
- fatty acid
- endoplasmic reticulum stress
- aortic stenosis