Validation of σ 2 R/TMEM97 as a neuropathic pain target: Specificity, human expression and mechanism of action.

Muhammad Saad YousufJames J SahnEric T DavidStephanie ShiersDanielle M RoyerChelsea D GarciaJennifer ZhangVeronica M HongAyesha AhmadBenedict J KolberDaniel J LieblStephen F MartinTheodore John Price

Published in: bioRxiv : the preprint server for biology (2023)

R/TMEM97-targeted therapeutics thus have the potential to offer effective pain relief without the side effects associated with currently available neuropathic pain medicines.

Keyphrases

neuropathic pain
spinal cord
spinal cord injury
endothelial cells
poor prognosis
small molecule
pluripotent stem cells
induced pluripotent stem cells
cancer therapy
binding protein
risk assessment
human health
pain management
structural basis