Meta-Analysis of Circulating Tumor Cell PD-L1 Expression and the Association with Clinical Outcomes in Non-Small Cell Lung Cancer.
Emmanuel AcheampongRebecca C AllsoppKaren PageMarc K WadsleyAaron B BeasleyR Charles CoombesJacqui A ShawElin Solomonovna GrayPublished in: Clinical chemistry (2024)
The average detection rate of PD-L1 + CTCs was comparable to the rate of PD-L1 expression in NSCLC tumors. There was a trend towards better PFS in ICI-treated NSCLC patients with PD-L1 + CTCs. Larger longitudinal studies on the association of PD-L1 + CTCs with clinical outcomes in NSCLC patients treated with ICIs are warranted.
Keyphrases
- circulating tumor cells
- circulating tumor
- small cell lung cancer
- advanced non small cell lung cancer
- systematic review
- case control
- single cell
- brain metastases
- cell therapy
- stem cells
- randomized controlled trial
- meta analyses
- epidermal growth factor receptor
- cross sectional
- bone marrow
- loop mediated isothermal amplification
- real time pcr