The immunomodulatory effects of tachykinins and their receptors.
Sahar KhorasaniNadia BoroumandFahimeh Lavi ArabSeyed Isaac HashemyPublished in: Journal of cellular biochemistry (2020)
Tachykinins (TKs) are a family of neuropeptides mainly expressed by neuronal and non-neuronal cell types, especially immune cells. Expression of TKs receptors on immune cell surfaces, their involvement in immune-related disorders, and therefore, understanding their immunomodulatory roles have become of particular interest to researchers. In fact, the precise understanding of TKs intervention in the immune system would help to design novel therapeutic approaches for patients suffering from immune disorders. The present review summarizes studies on TKs function as modulators of the immune system by reviewing their roles in generation, activation, development, and migration of immune cells. Also, it discusses TKs involvement in three main cellular mechanisms including inflammation, apoptosis, and proliferation.
Keyphrases
- oxidative stress
- end stage renal disease
- randomized controlled trial
- ejection fraction
- newly diagnosed
- poor prognosis
- single cell
- signaling pathway
- prognostic factors
- endoplasmic reticulum stress
- cell death
- cell therapy
- stem cells
- escherichia coli
- cerebral ischemia
- staphylococcus aureus
- long non coding rna
- binding protein