Sex differences in the expression of the endocannabinoid system within V1M cortex and PAG of Sprague Dawley rats.

Aidan LevineErika Liktor-BusaAustin A LipinskiSarah CoutureShreya BalasubramanianSue A AicherPaul R LanglaisTodd W VanderahTally Marie Largent-Milnes

Published in: Biology of sex differences (2021)

Our results suggest that sex differences exist in the endocannabinoid system in two CNS regions relevant to cortical spreading depression (V1M cortex) and descending modulatory networks in pain/anxiety (PAG). These basal differences in endogenous endocannabinoid mechanisms may facilitate the development of chronic pain conditions and may also underlie sex differences in response to therapeutic intervention.

Keyphrases

chronic pain
pain management
functional connectivity
sleep quality
randomized controlled trial
poor prognosis
depressive symptoms
binding protein
neuropathic pain