The EGF epidermal growth factor counteracts Tat modulation of human endogenous retroviruses of the W family in astrocytes.
Elena UleriClaudia PiuMaurizio CaocciGabriele IbbaCaterina SerraAntonina DoleiPublished in: Journal of neurovirology (2017)
Human astrocyte cells were exposed to HIV-Tat and/or epidermal growth factor (EGF), to monitor the expression of the neuropathogenic MSRV and Syncytin-1 elements of the HERV-W family of endogenous retroviruses and of TNFα. The results indicate that EGF counteracts Tat regulation of HERV-W/MSRVenv/Syncytin-1, throughout EGFR activation; this effect occurs by interfering with the induction of TNFα production by Tat. The novel effect of EGF counteraction of Tat-mediated regulation of the neuropathogenic HERV-Ws could be neuro-protective, but its actual role in the brain remains to be elucidated.
Keyphrases
- growth factor
- endothelial cells
- rheumatoid arthritis
- induced pluripotent stem cells
- induced apoptosis
- pluripotent stem cells
- poor prognosis
- hiv infected
- hiv testing
- resting state
- white matter
- cell cycle arrest
- tyrosine kinase
- hiv aids
- signaling pathway
- wound healing
- multiple sclerosis
- blood brain barrier
- cell proliferation
- functional connectivity
- cerebral ischemia
- cell death
- subarachnoid hemorrhage