Effects of quercetin in preclinical models of Parkinson's disease: A systematic review.
Camila de Oliveira VianMarcelo Augusto Germani MarinhoMagno da Silva MarquesMariana Appel HortMarcos Freitas CordeiroAna Paula HornPublished in: Basic & clinical pharmacology & toxicology (2024)
Parkinson's disease (PD) is a neurodegenerative disease that affects dopaminergic neurons, thus impairing dopaminergic signalling. Quercetin (QUE) has antioxidant and neuroprotective properties that are promising for the treatment of PD. This systematic review aimed to investigate the therapeutic effects of QUE against PD in preclinical models. The systematic search was performed in PubMed, Scopus and Web of Science. At the final screening stage, 26 articles were selected according to pre-established criteria. Selected studies used different methods for PD induction, as well as animal models. Most studies used rats (73.08%) and mice (23.08%), with 6-OHDA as the main strategy for PD induction (38.6%), followed by rotenone (30.8%). QUE was tested immersed in oil, nanosystems or in free formulations, in varied routes of administration and doses, ranging from 10 to 400 mg/kg and from 5 to 200 mg/kg in oral and intraperitoneal administrations, respectively. Overall, evidence from published data suggests a potential use of QUE as a treatment for PD, mainly through the inhibition of oxidative stress, neuroinflammatory response and apoptotic pathways.
Keyphrases
- systematic review
- oxidative stress
- cell death
- public health
- randomized controlled trial
- spinal cord
- stem cells
- combination therapy
- meta analyses
- spinal cord injury
- dna damage
- cell therapy
- anti inflammatory
- risk assessment
- fatty acid
- ischemia reperfusion injury
- brain injury
- insulin resistance
- heat stress
- big data
- high fat diet induced
- smoking cessation