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Subtype-selective agonists of plant hormone co-receptor COI1-JAZs identified from the stereoisomers of coronatine.

Kengo HayashiNobuki KatoKhurram BashirHaruna NomotoMisuzu NakayamaAndrea ChiniSatoshi TakahashiHiroaki SaitoRaku WatanabeYousuke TakaokaMaho TanakaAtsushi J NaganoMotoaki SekiRoberto SolanoMinoru Ueda
Published in: Communications biology (2023)
Severe genetic redundancy is particularly clear in gene families encoding plant hormone receptors, each subtype sharing redundant and specific functions. Genetic redundancy of receptor family members represents a major challenge for the functional dissection of each receptor subtype. A paradigmatic example is the perception of the hormone (+)-7-iso-jasmonoyl-L-isoleucine, perceived by several COI1-JAZ complexes; the specific role of each receptor subtype still remains elusive. Subtype-selective agonists of the receptor are valuable tools for analyzing the responses regulated by individual receptor subtypes. We constructed a stereoisomer library consisting of all stereochemical isomers of coronatine (COR), a mimic of the plant hormone (+)-7-iso-jasmonoyl-L-isoleucine, to identify subtype-selective agonists for COI1-JAZ co-receptors in Arabidopsis thaliana and Solanum lycopersicum. An agonist selective for the Arabidopsis COI1-JAZ9 co-receptor efficiently revealed that JAZ9 is not involved in most of the gene downregulation caused by COR, and the degradation of JAZ9-induced defense without inhibiting growth.
Keyphrases
  • signaling pathway
  • genome wide
  • binding protein
  • physical activity
  • mental health
  • depressive symptoms
  • arabidopsis thaliana
  • health information
  • early onset
  • drug induced
  • social support
  • high glucose