Metabolomic Study on the Therapeutic Effect of the Jianpi Yangzheng Xiaozheng Decoction on Gastric Cancer Treated with Chemotherapy Based on GC-TOFMS Analysis.
Chao HouHua-Jian ChuXiao-Jun DaiYin-Qiu WuZheng-Fei HeYan-Wei YuQing-Yun LuYan-Qing LiuXiao-Chun ZhangPublished in: Evidence-based complementary and alternative medicine : eCAM (2021)
The metabolic characteristics of patients with GC after chemotherapy are mainly various amino acid metabolic defects, especially L-glutamine, L-leucine, L-alloisoleucine, and L-valine. These defects lead to a series of problems, such as decreased tolerance and effectiveness of chemotherapy, increased side effects, decreased immunity, and shortened survival time. In addition, the remarkable upregulation of the gluconolactone level in patients with GC suggests the high proliferative activity of GC cells. Thus, gluconolactone may be used as a potential prognostic and diagnostic evaluation index. Moreover, JPYZXZ can reduce the incidence of ADRs and improve the life quality of patients by the correction of L-glutamine, L-leucine, L-alloisoleucine, and L-valine metabolism deficiency. In addition, gluconolactone metabolism is inhibited by JPYZXZ. Such inhibition may be one of the antitumor mechanisms of JPYZXZ.
Keyphrases
- locally advanced
- gas chromatography
- end stage renal disease
- amino acid
- newly diagnosed
- induced apoptosis
- randomized controlled trial
- chronic kidney disease
- mental health
- prognostic factors
- poor prognosis
- risk factors
- cell cycle arrest
- chemotherapy induced
- rectal cancer
- cell proliferation
- patient reported outcomes
- climate change
- cell death
- simultaneous determination