Precision Medicine Approach to Develop and Internally Validate Optimal Exercise and Weight-Loss Treatments for Overweight and Obese Adults With Knee Osteoarthritis: Data From a Single-Center Randomized Trial.
Xiaotong JiangAmanda E NelsonRebecca J ClevelandDaniel P BeaversTodd A SchwartzLiubov ArbeevaCarolina AlvarezLeigh F CallahanStephen MessierRichard F LoeserMichael R KosorokPublished in: Arthritis care & research (2021)
The precision medicine models supported the overall findings from IDEA that the D + E intervention was optimal for most participants, but there was evidence that a subgroup of participants would likely benefit more from diet alone for 2 outcomes.
Keyphrases
- knee osteoarthritis
- weight loss
- bariatric surgery
- physical activity
- randomized controlled trial
- roux en y gastric bypass
- gastric bypass
- high intensity
- electronic health record
- glycemic control
- big data
- type diabetes
- adipose tissue
- metabolic syndrome
- machine learning
- data analysis
- skeletal muscle
- insulin resistance
- artificial intelligence