Sutureless valves-are we there yet? Evidence from the PERSIST-AVR trial.
Pradeep NarayanPublished in: Indian journal of thoracic and cardiovascular surgery (2021)
Sutur eless valves have emerged as another option for implantation of a biological valve. Several benefits of sutureless valves have been reported in the literature. However, concerns have been raised over increased incidence of para-valvular leak and need for permanent pacemaker implantation. Most of the evidence has been obtained from observational and retrospective single institutional series. The Perceval Sutureless Implant Versus Standard-Aortic Valve Replacement (PERSIST-AVR) trial is the first multicentric randomized control trial to compare sutureless valves with standard bio-prosthesis. Evidence from this trial has been critically analyzed in this review.
Keyphrases
- aortic valve replacement
- aortic valve
- phase iii
- aortic stenosis
- transcatheter aortic valve implantation
- phase ii
- transcatheter aortic valve replacement
- study protocol
- clinical trial
- open label
- ejection fraction
- double blind
- placebo controlled
- systematic review
- cross sectional
- mitral valve
- randomized controlled trial
- risk factors
- soft tissue
- vena cava