Down-regulation of hepatic expression of GHR/STAT5/IGF-1 signaling pathway fosters development and aggressiveness of HCV-related hepatocellular carcinoma: Crosstalk with Snail-1 and type 2 transforming growth factor-beta receptor.
Mona A Abu El-MakaremMariana F KamelAhmed A MohamedHisham A AliMahmoud R MohamedAlaa El-Deen M MohamedAhmed M El-SaidMahmoud G AmeenAlshymaa A HassnineHatem A HassanPublished in: PloS one (2022)
Decreased expression of GHR/STAT5/IGF-1 signaling pathway may have a role in development, aggressiveness, and worse outcome of HCV-associated HCC irrespective of the liver functional status. Snail-1 and TGFBR2 as inducers of EMT may be key players. However, large prospective multicenter studies are needed to validate these results.