β-Catenin and TCFs/LEF signaling discordantly regulate IL-6 expression in astrocytes.
KaReisha F RobinsonSrinivas D NarasipuraJennillee WallaceEthan M RitzLena Al-HarthiPublished in: Cell communication and signaling : CCS (2020)
IL-6 regulation in human astrocytes engages a discordant interaction between β-catenin and TCF/LEF. These findings are intriguing given that no role for β-catenin nor TCFs/LEF to date is associated with IL-6 regulation and suggest that β-catenin expression in astrocytes is a critical regulator of anti-inflammatory responses and its disruption can potentially mediate persistent neuroinflammation. Video Abstract.