Cross-Sectional and Prospective Relationships Between Neuroticism and Depressive Symptoms Among College Students: The Mediating Role of Loneliness.

High levels of neuroticism are associated with an increased risk of depression. The mechanisms for this association are still unclear. This study investigated loneliness, a pervasive negative human emotion linked to depressive symptoms, as a potential mediator. Data were collected from 739 college students (71.6% females; mean age = 18.47, SD = .87) at two times points through 3 years. Self-report questionnaires were administered to assess neuroticism, loneliness, and depressive symptoms. Cross-sectional analyses of the baseline data suggested that loneliness mediates the association between neuroticism and depressive symptoms. Prospective analyses with two-wave data further prove that baseline neuroticism can predict the changes in depressive symptoms, and changes in loneliness sequentially mediated this association. These findings suggest a possibility of developing interventions for loneliness to interrupt the association between neuroticism and poorer mental health outcomes among college students.