Piceatannol Prevents Colon Cancer Progression via Dual-Targeting to M2-Polarized Tumor-Associated Macrophages and the TGF-β1 Positive Feedback Signaling Pathway.

Yi-Shiou ChiouYi-Ming LanPei-Sheng LeeQianyu LinNagabhushanam KalyanamChi-Tang HoMin-Hsiung Pan

Published in: Molecular nutrition & food research (2022)

These novel findings demonstrate that PIC is a potent TGF-β1/TGF-βR1 pathway inhibitor and TME modulator for preventing tumor progression and metastasis in CRC by reeducating TAMs.

Keyphrases

transforming growth factor
signaling pathway
epithelial mesenchymal transition
poor prognosis
pi k akt
cancer therapy
induced apoptosis