Activation of metabolite receptor GPR91 promotes platelet aggregation and transcellular biosynthesis of leukotriene C4.
Xiao TangDavid FuchsShuai TanMette TrauelsenThue W SchwartzCraig E WheelockNailin LiJesper Z HaeggströmPublished in: Journal of thrombosis and haemostasis : JTH (2020)
Succinate signals through GPR91 to promote biosynthesis of eicosanoids, which contribute to platelet aggregation/activation and potentially vascular inflammation. Hence, GPR91 may be a suitable target for pharmacological intervention in atherothrombotic conditions.