EnvR is a potent repressor of acrAB transcription in Salmonella.
Jessica M A BlairPauline SiasatHelen E McNeilAbigail ColcloughVito RicciAmelia J LawlerHind AbdalaalMichelle M C BucknerAlison BaylayStephen J W BusbyLaura J V PiddockPublished in: The Journal of antimicrobial chemotherapy (2022)
In summary, we show that EnvR is a potent repressor of acrAB transcription in Salmonella, and can override binding by RamA so preventing MDR to clinically useful drugs. Finding novel tools to increase EnvR expression may form the basis of a new way to prevent or treat MDR infections.