Safflower yellow improves insulin sensitivity in high-fat diet-induced obese mice by promoting peroxisome proliferator-activated receptor-γ2 expression in subcutaneous adipose tissue.
Kemin YanXiangqing WangHuijuan ZhuHui PanLinjie WangHongbo YangMeijuan LiuMing JinBaoxia ZangFengying GongPublished in: Journal of diabetes investigation (2020)
SY could reduce fat mass, decrease glucose levels and improve insulin sensitivity in high-fat diet-induced obese mice. The probable mechanism is to increase PPARγ2 expression by stimulating PPARγ2 promoter activities, further increasing the expression of insulin signaling pathway-related genes in subcutaneous adipose tissue.
Keyphrases
- insulin resistance
- high fat diet induced
- adipose tissue
- high fat diet
- poor prognosis
- type diabetes
- signaling pathway
- metabolic syndrome
- glycemic control
- skeletal muscle
- gene expression
- binding protein
- epithelial mesenchymal transition
- long non coding rna
- transcription factor
- fatty acid
- blood pressure
- cell proliferation
- oxidative stress