FACT regulates pluripotency through proximal and distal regulation of gene expression in murine embryonic stem cells.

David C KleinSantana M LardoKurtis N McCannellSarah J Hainer

Published in: BMC biology (2023)

We propose that FACT maintains cellular pluripotency through a precise nucleosome-based regulatory mechanism for appropriate expression of both coding and non-coding transcripts associated with pluripotency.

Keyphrases

embryonic stem cells
gene expression
poor prognosis
dna methylation
minimally invasive
transcription factor
binding protein
cell fate