Personalized Biomarker-Based Umbrella Trial for Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: KCSG HN 15-16 TRIUMPH Trial.

Bhumsuk Keam Min Hee HongSeong Hoon ShinSeong Gu Heo Ji Eun KimHee Kyung AhnYun-Gyoo Lee Keon Uk ParkTak YunKeun-Wook Lee Sung-Bae Kim Sang-Cheol LeeMin Kyoung KimSang Hee Cho So Yeon OhSang-Gon ParkShinwon HwangByung-Ho NamSangwoo Kim Hye Ryun Kim Hwan Jung Yunnull null

Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2023)

To our knowledge, this study is the first biomarker-driven umbrella trial for platinum-refractory HNSCC using matched molecular targeted agents. We found that NGS-based genomic phenotyping was methodologically feasible and applicable.

Keyphrases

phase iii
study protocol
phase ii
clinical trial
healthcare
squamous cell carcinoma
small cell lung cancer
randomized controlled trial
open label
high throughput
gene expression
copy number
meta analyses
drug delivery