A new graphene-based nanomaterial increases lipolysis and reduces body weight gain through integrin linked kinase (ILK).
Sergio de FrutosMercedes GrieraMaria Del Prado Lavín-LópezMartín Martínez-RoviraJosé António Martínez-RoviraManuel Rodríguez-PuyolDiego Rodríguez-PuyolPublished in: Biomaterials science (2023)
GMC is safe and effective in reducing hypertrophied scWAT weight when topically applied and it can be considered of interest in anti-obesogenic strategies. GMC increases lipolysis and reduces adipogenesis inside adipocytes by mechanisms that imply the activation of INTB1, the overexpression of ILK, and changes in the expression and activity of several markers related to fat metabolism.
Keyphrases
- weight gain
- adipose tissue
- body mass index
- birth weight
- insulin resistance
- poor prognosis
- weight loss
- cell proliferation
- high fat diet induced
- transcription factor
- physical activity
- binding protein
- protein kinase
- fatty acid
- type diabetes
- long non coding rna
- carbon nanotubes
- metabolic syndrome
- ionic liquid
- gestational age