A Single Arm Phase 2 Trial of Trametinib in Patients With Locally Advanced or Metastatic Epithelioid Hemangioendothelioma.
Scott M SchuetzeKarla V BallmanRachel S HeiseKristen N GanjooElizabeth J DavisSuzanne GeorgeMelissa A BurgessEdwin ChoyDale R ShepardGabriel TinocoAngela C HirbeCiara M KellySteven AttiaHari A DeshpandeGary K SchwartzBrittany L SiontisRichard F RiedelMargaret von MehrenErin KozlowskiHelen X ChenCaroline AstburyBrian P RubinPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Trametinib was associated with reduction in EHE-related pain and median PFS of more than 6 months providing palliative benefit in patients with advanced EHE, but the trial did not meet the ORR goal.
Keyphrases
- locally advanced
- squamous cell carcinoma
- chronic pain
- rectal cancer
- neoadjuvant chemotherapy
- small cell lung cancer
- study protocol
- pain management
- palliative care
- phase iii
- neuropathic pain
- clinical trial
- radiation therapy
- phase ii study
- phase ii
- advanced cancer
- randomized controlled trial
- lymph node
- spinal cord injury
- double blind
- postoperative pain