Novel self-amplificatory loop between T cells and tenocytes as a driver of chronicity in tendon disease.

Emma Garcia-Melchor Giacomo Cafaro Lucy MacDonaldLindsay A N CroweShatakshi SoodMichael McLeanUmberto G FazziIain B McInnesMoeed Akbar Neal L Millar

Published in: Annals of the rheumatic diseases (2021)

Interaction between T cells and tenocytes induces the expression of inflammatory cytokines/chemokines in tenocytes, alters collagen composition favouring collagen 3 and self-amplifies T cell activation via an auto-regulatory feedback loop. Selectively targeting this adaptive/stromal interface may provide novel translational strategies in the management of human tendon disorders.

Keyphrases

transcription factor
endothelial cells
anterior cruciate ligament reconstruction
poor prognosis
rotator cuff
wound healing
tissue engineering
bone marrow
induced pluripotent stem cells
pluripotent stem cells
cancer therapy
binding protein
long non coding rna