Immunological drivers of amyotrophic lateral sclerosis.
Tania F GendronLeonard PetrucelliPublished in: Science translational medicine (2023)
Amyotrophic lateral sclerosis (ALS), a devastating motor neuron disease involving complex genetic and environmental factors, is associated with neuroinflammation. Preclinical and clinical studies support immune system involvement in ALS pathogenesis, thereby spurring investigations into potential pathogenic mechanisms, immune response biomarkers, and ALS therapeutics.
Keyphrases
- amyotrophic lateral sclerosis
- immune response
- small molecule
- genome wide
- lipopolysaccharide induced
- cognitive impairment
- lps induced
- stem cells
- cell therapy
- copy number
- dna methylation
- risk assessment
- mesenchymal stem cells
- human health
- bone marrow
- cerebral ischemia
- brain injury
- climate change
- subarachnoid hemorrhage