Variants in the GPR146 Gene Are Associated With a Favorable Cardiometabolic Risk Profile.

Antoine Rimbert Ming Wai YeungNawar DalilaChris H L Thio Haojie YuNatalia LoaizaFederico Oldoni Adriaan van der Graaf Siqi Wang M Abdullah SaidLisanne L BlauwAurore GirardeauLise Bray Amandine CaillaudVincent W BloksMarie MarrecPhilippe MoulinPatrick C N Rensen Bart van de Sluis Harold Snieder Mathilde Di Filippo Pim van der HarstAnne Tybjaerg-HansenPhilip ZimmermanBertrand Cariou Jan Albert Kuivenhoven

Published in: Arteriosclerosis, thrombosis, and vascular biology (2022)

variants have a beneficial cardiometabolic risk profile, but it remains to be shown whether genetic or pharmaceutical inhibition of GPR146 protects against atherosclerosis in humans.

Keyphrases

copy number
genome wide
cardiovascular disease
fatty acid
dna methylation