Akebia saponin D acts via the PPAR-gamma pathway to reprogramme a pro-neurogenic microglia that can restore hippocampal neurogenesis in mice exposed to chronic mild stress.
Jinqiang ZhangQin LiuDapeng SuLiangyuan LiChenghong XiaoHui HeZili YouTao ZhouPublished in: CNS neuroscience & therapeutics (2023)
These results suggested that ASD acts via the PPAR-γ pathway to induce a pro-neurogenic microglia in dentate gyrus of CMS mice that can increase BDNF expression and promote NSPC proliferation, survival, and neurogenesis.
Keyphrases
- spinal cord injury
- high fat diet induced
- inflammatory response
- insulin resistance
- cerebral ischemia
- neuropathic pain
- autism spectrum disorder
- poor prognosis
- anti inflammatory
- stress induced
- signaling pathway
- attention deficit hyperactivity disorder
- neural stem cells
- fatty acid
- adipose tissue
- type diabetes
- spinal cord
- brain injury
- subarachnoid hemorrhage
- drug induced
- intellectual disability