PTEN loss drives resistance to the neddylation inhibitor MLN4924 in glioblastoma and can be overcome with TOP2A inhibitors.
Shayesteh R FerdosiBrett TaylorMatthew LeeNanyun TangSen PengRita BybeeGeorge ReidLauren HartmanKrystine Garcia-MansfieldRitin SharmaPatrick PirrotteJianhui MaAlison D ParisianFrank B FurnariHarshil D DhruvMichael E BerensPublished in: Neuro-oncology (2022)
We show that PTEN status serves as both a novel biomarker for MLN4924 response in GBM and reveals a vulnerability to TOP2A inhibitors in combination with MLN4924.
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