Gut microbiome-mediated modulation of hepatic cytochrome P450 and P-glycoprotein: impact of butyrate and fructo-oligosaccharide-inulin.

Jacinta WalshCassandra E GheorgheJoshua M LyteMarcel van de WouwMarcus BoehmeTimothy G DinanJohn F CryanBrendan T GriffinGerard ClarkeNiall P Hyland

Published in: The Journal of pharmacy and pharmacology (2020)

The expression of hepatic genes implicated in drug metabolism and transport displays sensitivity to the microbiome, microbiome-derived metabolites and a microbial-targeted intervention. Our study may provide the impetus to explore microbiota-targeted interventions in normalising host metabolic activity and reducing inter-individual variability in drug pharmacokinetics.

Keyphrases

cancer therapy
randomized controlled trial
poor prognosis
physical activity
microbial community
ms ms
adverse drug
emergency department
drug induced
drug delivery
binding protein
gene expression
genome wide identification