Proteomic Analysis of Liver from Human Lipoprotein(a) Transgenic Mice Shows an Oxidative Stress and Lipid Export Response.
Euan J RodgerCarolyn M PorteousGregory T JonesMichael LeggeTorsten KleffmannSally P A McCormickPublished in: BioMed research international (2018)
The presence of human LDL and Lp(a) in mice promotes an enhanced flux of lipids into the liver which elicits an antioxidant and lipid export response before the onset of atherosclerosis. The antioxidant response can be reproduced in human liver cells treated with Lp(a).