Palladium(II)-Catalyzed Mono- and Bis-alkenylation of N-Acetyl-2-aminobiaryls through Regioselective C-H Bond Activation.

Pratheepkumar AnnamalaiKou-Chi HsuSelvam RajuHuan-Chang HsiaoChih-Wei ChouGu-Ying LinCheng-Ming HsiehPei-Ling ChenYi-Hung LiuShih-Ching Chuang

Published in: The Journal of organic chemistry (2018)

We developed palladium-catalyzed oxidative coupling of olefins with N-acyl 2-aminobiaryls through a sequence of ortho C-H bond activation/alkene insertion/reductive elimination. Furthermore, we controlled the selectivity of mono- and bis-alkenylation products with the solvent effect. The developed protocol was promising for a broad substrate scope ranging from activated olefins with a wide variety of functional groups to unactivated olefins.

Keyphrases

ionic liquid
room temperature
randomized controlled trial
fatty acid
structural basis
electron transfer
solar cells
solid state