Expression profile of human porcine endogenous retrovirus A receptors (HuPAR-1, HuPAR-2) and transcription factor activator protein-2γ (TFAP-2C) genes in infected human fibroblasts-Model in vitro.
Emilia WojdasKrzysztof ŁopataRoman NowakMagdalena Kimsa-DudekPaweł ŁopataUrszula MazurekPublished in: Xenotransplantation (2019)
As reported previously, treatment of NHDF cells with LPS decreased PERV-A provirus integration and increased PERV-A mRNA expression. PERV infection alone did not modulate the expression of HuPAR-1, HuPAR-2, and TFAP-2C. This is the first study analyzing the expression profile of HuPAR-1, HuPAR-2, and TFAP-2C in NHDF cells treated by LPS and/or infected by PERVs.
Keyphrases
- induced apoptosis
- endothelial cells
- transcription factor
- cell cycle arrest
- inflammatory response
- poor prognosis
- pluripotent stem cells
- endoplasmic reticulum stress
- immune response
- genome wide
- oxidative stress
- gene expression
- toll like receptor
- signaling pathway
- small molecule
- dna methylation
- extracellular matrix
- dna binding
- combination therapy
- smoking cessation
- protein protein