Endophilin A2 deficiency protects rodents from autoimmune arthritis by modulating T cell activation.
Ulrika NorinCarola RintischLiesu MengFlorian ForsterDiana EkmanJonatan TuncelKatrin KlockeJohan BäcklundMin YangMichael Y BonnerGonzalo Fernandez LahoreJaime JamesKlementy ShchetynskyMaria BergquistInger GjertssonNorbert HübnerLiselotte BäckdahlRickard HolmdahlPublished in: Nature communications (2021)
The introduction of the CTLA-4 recombinant fusion protein has demonstrated therapeutic effects by selectively modulating T-cell activation in rheumatoid arthritis. Here we show, using a forward genetic approach, that a mutation in the SH3gl1 gene encoding the endocytic protein Endophilin A2 is associated with the development of arthritis in rodents. Defective expression of SH3gl1 affects T cell effector functions and alters the activation threshold of autoreactive T cells, thereby leading to complete protection from chronic autoimmune inflammatory disease in both mice and rats. We further show that SH3GL1 regulates human T cell signaling and T cell receptor internalization, and its expression is upregulated in rheumatoid arthritis patients. Collectively our data identify SH3GL1 as a key regulator of T cell activation, and as a potential target for treatment of autoimmune diseases.
Keyphrases
- rheumatoid arthritis
- rheumatoid arthritis patients
- disease activity
- poor prognosis
- binding protein
- signaling pathway
- genome wide
- oxidative stress
- copy number
- metabolic syndrome
- dendritic cells
- drug induced
- systemic lupus erythematosus
- ankylosing spondylitis
- interstitial lung disease
- immune response
- long non coding rna
- electronic health record
- deep learning
- artificial intelligence
- amino acid
- idiopathic pulmonary fibrosis
- replacement therapy
- data analysis