Multicentre validation of a modified EUCAST MIC testing method and development of associated epidemiologic cut-off (ECOFF) values for rezafungin.
Maiken Cavling ArendrupSevtap Arikan-AkdagliMariana CastanheiraJesus Vicente GuineaJeffrey B LockeJoseph MeletiadisÓscar ZaragozaPublished in: The Journal of antimicrobial chemotherapy (2022)
The modified EUCAST method significantly improved inter-laboratory variation, identified wild-type populations and allowed perfect separation of wild-type and fks mutants except for two isolates harbouring weak mutations. These consensus WT-UL have been accepted as ECOFFs and will be used for rezafungin breakpoint setting.