Protective alleles and precision healthcare in crewed spaceflight.
Lindsay A RutterMatthew J MacKayHenry CopeNathaniel J SzewczykJang-Keun KimEliah G OverbeyBraden T TierneyMasafumi MurataniBen LammDaniela BezdanAmber M PaulMichael A SchmidtGeorge M ChurchStefania GiacomelloChristopher E MasonPublished in: Nature communications (2024)
Common and rare alleles are now being annotated across millions of human genomes, and omics technologies are increasingly being used to develop health and treatment recommendations. However, these alleles have not yet been systematically characterized relative to aerospace medicine. Here, we review published alleles naturally found in human cohorts that have a likely protective effect, which is linked to decreased cancer risk and improved bone, muscular, and cardiovascular health. Although some technical and ethical challenges remain, research into these protective mechanisms could translate into improved nutrition, exercise, and health recommendations for crew members during deep space missions.
Keyphrases
- healthcare
- endothelial cells
- public health
- mental health
- physical activity
- induced pluripotent stem cells
- health information
- pluripotent stem cells
- resistance training
- clinical practice
- bone mineral density
- systematic review
- randomized controlled trial
- health promotion
- soft tissue
- body composition
- combination therapy
- replacement therapy
- health insurance
- postmenopausal women
- affordable care act